Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers

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Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers

BACKGROUND Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system. Tendons connect bone to muscle and transmit forces on which locomotion entirely depends. Due to trauma, overuse and age-related degeneration, many people suffer from acute or chronic tendon injuries. Owing to their hypovascularity and hypocellularity, tendinopath...

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Rotator cuff tears represent the most common shoulder injuries in the United States. The debilitating effect of this degenerative condition coupled with the high incidence of failure associated with existing graft choices underscores the clinical need for alternative grafting solutions. The 2 critical design criteria for the ideal tendon graft would require the graft to not only exhibit physiol...

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ژورنال

عنوان ژورنال: Journal of Experimental Orthopaedics

سال: 2018

ISSN: 2197-1153

DOI: 10.1186/s40634-017-0117-1